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Colorectal cancer can be prevented, mainly with healthy lifestyle changes. The nutritional recommendations of the American Cancer Society include an adequate intake of fruits and vegetables in the diet.
He grape seed extract, commonly consumed as a nutritional supplement, has aroused great interest mainly due to the high antioxidant content in form of proanthocyanidins. The antioxidant capacity of this extract has been shown to be greater than that of other known antioxidants such as vitamin C and E.
There are many investigations that have been done in this regard.
Among them, we highlight the one published in Cancer Letters magazine in which it was found that grape seed extractinhibits the growth of cancer cellsin experiments with cultured cancer cells. Noting that the benefits of grape seed extract were increased in the more advanced stages of cancer, unlike chemotherapy that decreases its effectiveness in advanced stages of cancer.
Colorectal cancer is generally difficult to treat with chemotherapy when it is found at an advanced stage (stage IV). In these advanced stages, colorectal cancer cells are resistant to chemotherapy due to genetic mutations.
It is estimated that a colorectal cancer cell has more than 11,000 mutations that differentiate it from a healthy cell. He grape seed extract is able to eliminate mutations, so it may be more effective than chemotherapy in the treatment of colorectal cancer.
A similar study previously published in the journal Carcinogenesis found that, in both cell culture and mice, grape seed extract attacked cancer cells without harming healthy cells. Grapeseed extract appears to create a unfavorable environment for the growth of cancer cells.
Although a large part of the studies suggests that grape seeds are a source of phytochemicals with potential in the treatment and prevention of cancer, the other parts of the grape such as the skin, the whole grape or the raisins have also shown potential efficacy against cancer in various preclinical and clinical studies.
Another of the phytochemicals present in grapes is resveratrol, found in abundance in grape skins, peanuts, tea, and wine. There are a large number of scientific studies that have demonstrated the anticancer and cancer chemopreventive efficacy of reverastrol in numerous animal and cell culture models of cancer.